HOW DIABETES AFFECTS WOUND HEALING
Hi, Today I am going to discuss how diabetes affects wound Healing. Actually we know that wound healing has been a major problem for Diabetic patients and Many mechanisms involved in it. Now I am going to discuss few things on it.
There were many factors
which affects wound healing in diabetic individuals. Some of the basic
mechanisms involved are :
Ø Elevated blood sugar levels
↓
Deposition of collagen on endothelium
of arteries
↓
Stiffening of
Arteries
↓
Narrowing of Blood vessels
↓
Poor Circulation (RBC,
WBC)
↓
Decreased blood
flow ,Oxygen to Wounds
And
decreased immune response
↓
Delayed Wound Healing.
Hypoxia and Ischeamia delays wound healing
where as Hyperoxia enhances wound
healing through the activation of eNOS, (Endothelial Nitric oxide Synthase) which
produces nitric oxide and thereby
stimulating the production of endothelial progenitor cells from bonemarrow, which are essential
for the formation of blood vessels and wound healing.
Ø Wound
Healing is Enhanced during
I)
Increased oxygen levels (hyperoxia)
↓
↑ Mobilization
of Endothelial Progenitor cells (derived from bone marrow )
↓
Travels
to sites of injury i.e., peripheral
blood circulation
II)
The High oxygen levels
(hyperoxia)
↓
↑ activation of bonemarrow
enzyme Endothelial Nitric Oxide Synthase (eNOS)
↓
Stimulated nitric oxide production
↓
Production of
greater no. of Endothelial progenitor Cells.
↓
Essential
for formation of blood vessels and wound
healing.
The above mentioned mechanisms responsible for wound healing in diabetic patients.
Thanks for Reading
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